id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-301303-44sk478e	Wu, Vin-Cent	Renal hypouricemia is an ominous sign in patients with severe acute respiratory syndrome	2008-02-21		.txt	text/plain	3128	193	54	Conclusion: One fourth of patients with SARS developed hypouricemia, which might result from a defect in renal UA handling and was associated with a high serum IL-8 level. Serum levels of the proinflammatory cytokines IL-6, IL-8, and TNF-␣ were measured in 16 patients (6 hypouricemic, 10 normouricemic) during their UA excretion studies. The inverse correlation between serum UA level and FE UA indicates that the hypouricemia in patients with SARS resulted from an abnormal increase in UA excretion during SARS-CoV infection. 27 Our study showed that the lowest serum UA level occurred days 7 to 9 after fever onset, when the cytokine storm of patients with SARS usually occurred. 19 The present study shows that hypouricemic patients with SARS had a poor outcome, especially in terms of respiratory failure, compared with normouricemic patients. In summary, hypouricemia resulting from abnormal renal urate handling is not rare in patients with SARS-CoV infection and may reflect the severity of disease and predict poor patient outcomes.	./cache/cord-301303-44sk478e.txt	./txt/cord-301303-44sk478e.txt