id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-298920-1lc2xf7u	Bello-Perez, Melissa	Canonical and Noncanonical Autophagy as Potential Targets for COVID-19	2020-07-05		.txt	text/plain	6863	326	40	Along this line, the generation of these coronavirus-induced autophagosomes requires the PtdIns3P-enrichment of the ER membrane outer leaflet, and the recruitment of ZFYVE1/DFCP1 (a key protein in omegasome formation), WIPI1/2, ATG5 and LC3-II (all components of the autophagic machinery), and SQSTM1/p62 (a receptor protein for selective autophagy) [31, 50, 51] . Briefly, chloroquine, apart from disorganizing the Golgi, induces lysosomal alkalinization, which prevents amphisome/autophagosome-lysosome fusion and blocks the vesicle trafficking system [53] [54] [55] 93] , which potentially affects the replication cycle of coronavirus systemically, including their entry, which is mediated by pH-dependent endocytosis and requires a low pH for the S protein to trigger its membrane fusion activity [94, 95] . Nitazoxanide is another late-stage autophagy blocker [96] that shows high anti-SARS-CoV-2 activity in cell cultures (IC 50 : 2.12 µM) [97] , although it should be considered that its main metabolite, tizoxanide, induces autophagy by inhibiting the PI3K-AKT-MTOR pathway [98] .	./cache/cord-298920-1lc2xf7u.txt	./txt/cord-298920-1lc2xf7u.txt