id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-297989-4grwa4ab	Li, Yunjin	Systematic profiling of ACE2 expression in diverse physiological and pathological conditions for COVID‐19/SARS‐CoV‐2	2020-07-08		.txt	text/plain	1616	89	46	Since the expression profile of ACE2, a crucial cell entry receptor for SARS‐CoV‐2, could indicate the susceptibility to SARS‐CoV‐2 infection, here we systematically dissected ACE2 expression using large‐scale multi‐omics data from 30 organs/tissues, 33 cancer types and some common chronic diseases involving >28 000 samples. Furthermore, the patients with common chronic diseases regarding angiocardiopathy, type 2 diabetes, liver, pneumonia and hypertension were also with higher ACE2 expression compared to related controls, which were validated using independent data sets. Collectively, our study may reveal a novel important mechanism that the patients with certain cancers and chronic diseases may express higher ACE2 expression compared to the individuals without diseases, which could lead to their higher susceptibility to multi‐organ injury of SARS‐CoV‐2 infection. Here, we systematically analysed ACE2 expression using largescale multi-omics data from a variety of organs/tissues and cancer types, as well as the common chronic diseases of heart, liver, diabetes, pneumonia and hypertension involving a total of >28 000 samples.	./cache/cord-297989-4grwa4ab.txt	./txt/cord-297989-4grwa4ab.txt