id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-297463-mmmwi8de	Hsu, You-Ren	Detection of Severe Acute Respiratory Syndrome (SARS) Coronavirus Nucleocapsid Protein Using AlGaN/GaN High Electron Mobility Transistors	2013-03-15		.txt	text/plain	934	61	58	title: Detection of Severe Acute Respiratory Syndrome (SARS) Coronavirus Nucleocapsid Protein Using AlGaN/GaN High Electron Mobility Transistors AlGaN/GaN high electron mobility transistors (HEMTs) were used to detect the SARS coronavirus (SARS-CoV) nucleocapsid protein interaction without fluorescent labeling. We demonstrated AlGaN/GaN was highly potential in constructing a semiconductor-based-sensor binding assay to extract the dissociation constants of nucleic acid-protein interaction. Here, we demonstrated using the AlGaN/GaN HEMT-based sensors to detect the SARS-CoV CTD s protein. Here, we demonstrated that the AlGaN/GaN HEMTs also have the capability of detecting nucleic acid-protein interaction with high sensitivity. The detection limit of AlGaN/GaN HEMTs sensor for SARS-CoV N protein of dsDNA immobilized device was 0.003 nM, and two orders lower than AMPs immobilized nanowire FET 17 . In summary, AlGaN/GaN HEMTs can detect the nucleic acid binding protein at a low detection limit.	./cache/cord-297463-mmmwi8de.txt	./txt/cord-297463-mmmwi8de.txt