id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-296762-sc6crkkw	Ali, Fedaa	ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity	2020-08-20		.txt	text/plain	808	59	60	title: ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity Here, we combined ACE2 coding variants analysis in different populations and computational chemistry calculations to probe the effects on SARS-CoV-2/ACE2 interaction. Furthermore, the structure of ACE2 was trimmed by removing residues from P733 to the end of The electrostatic and the van der Waal contribution to the interaction energies of SARS-CoV-108 2/ACE2 were compared between single mutated and WT protein at pH =7 ( Fig. 2A) . Based on our calculations, G211R mutant is shown to induce the largest increase 112 in the binding energy between SARS-CoV-2 and ACE2, where the binding is more favorable by 113 ~ 7.6 Kcal/mol than the WT. SARS-CoV-2/ACE2 interface in the 123 WT protein and corresponding mutants is showed to be a dominated by van der Waals 124 interactions, which accounts for more than 60% of the interaction energy.	./cache/cord-296762-sc6crkkw.txt	./txt/cord-296762-sc6crkkw.txt