id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-296339-23yi8so0	Mok, Wendy	Non-Molecular-Clock-Like Evolution following Viral Origins in Homo sapiens	2007-09-26		.txt	text/plain	1395	75	43	We used computational methods to examine the extent to which this practice can result in inaccurate 'retrodiction.' Failing to account for dynamic molecular evolution can affect greatly estimating index case dates, resulting in an overestimated age for the SARS-CoV-human infection, for instance. Herein, we show that adopting molecular clock assumptions can yield inaccurate estimated origin times, considering as an example data from the Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) infection in humans. Recognizing that this change in substitution rate would violate a molecular clock assumption and could cause pairwise genetic distances to yield inaccurate evolutionary divergence estimates (especially if genetic distance calculations were performed with respect to a reference sequence representing an hypothetical common ancestor), we quantifi ed the extent to which failing to account for dynamic SARS-CoV evolution might affect estimating an origin time.	./cache/cord-296339-23yi8so0.txt	./txt/cord-296339-23yi8so0.txt