id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-296148-za3j19k5	Rosenzweig, Ivana	Does damage to hypothalamic paraventricular nucleus underlie symptoms of ultradian rhythm disorder and an increased anxiety in coronavirus disease 2019?	2020-08-17		.txt	text/plain	1706	80	34	Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may directly target parts of the brain, more specifically the hypothalamus and its paraventricular nucleus, and possibly lead to increased prevalence of anxiety disorders. Any changes in the PVN circuitries, due to their major control over most of neuro-endocrine axes and neuronal autonomic centers, may cause robust alteration in homeostatic regulation, and through influence on regulatory brain centers impact on sleep and wakefulness, increased propensity to affective disorders and anxiety, and alteration of ultradian rhythms. We correspondingly argue a direct SARS-CoV-2 effect on the specific part of the brain's hypothalamic paraventricular nucleus (PVN) circuitry ( Figure 1 ) as a neurologic mechanism that may, at least in part, underlie previously reported ultradian disruption, and that may lead to an increased anxiety symptomatology (7) . We propose that SARS-CoV-2 may target the distinct ACE2-tagged part of the PVN-subcircuitry (8), via a direct monosynaptic subfornical route (Figure 1 ), leading to the pleomorphic dysautonomic ultradian presentation, which is further compounded with nocturnal sleep fragmentation.	./cache/cord-296148-za3j19k5.txt	./txt/cord-296148-za3j19k5.txt