id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-296095-onereai5	Vardhan, Seshu	In silico ADMET and molecular docking study on searching potential inhibitors from limonoids and triterpenoids for COVID-19	2020-07-28		.txt	text/plain	5483	274	48	Considering the published literature on medicinal importance, 154 phytochemicals with analogous structure from limonoids and triterpenoids were selected to search potential inhibitors for the five therapeutic protein targets of SARS-CoV-2, i.e., 3CLpro (main protease), PLpro (papain-like protease), SGp-RBD (spike glycoprotein-receptor binding domain), RdRp (RNA dependent RNA polymerase) and ACE2 (angiotensin-converting enzyme 2). In this manuscript, 154 phytochemicals from limonoids and triterpenoids were selected by considering their known medicinal importance to search potential hits for the five therapeutic protein targets of SARS-CoV-2, i.e., 3CLpro (main protease), PLpro (papain-like protease), SGp-RBD (spike glycoprotein-receptor binding domain), RdRp (RNA dependent RNA polymerase) and ACE2 (angiotensin-converting enzyme 2). Our recent molecular docking study on searching inhibitors for COVID-19 revealed that the phytochemical limonin known for inhibiting the replication of retroviruses like HTLV-I and HIV-1 showed the higher dock score towards the protein targets RdRp and ACE2 of SARS-CoV-2, and comparatively higher than the drug hydroxychloroquine [17] .	./cache/cord-296095-onereai5.txt	./txt/cord-296095-onereai5.txt