id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-295830-1sbnewog	Kim, Sung-Jae	A Novel Synonymous Mutation of SARS-CoV-2: Is This Possible to Affect Their Antigenicity and Immunogenicity?	2020-05-14		.txt	text/plain	2371	133	50	Therefore, we analyzed the S gene sequences of SARS-CoV-2 to better understand the antigenicity and immunogenicity of this virus in this study. The region containing this mutation point was confirmed as a B-cell epitope located in the S1 domain, and SARS-CoV-2b strains exhibited severe reduced antigenic indexes compared to SARS-CoV-2a in this area. Generally, several types of coronavirus are divided into subtypes depending on amino acid mutations in S gene sequences, and molecular analysis based on the S gene can provide insights into antigenicity, immunogenicity, or evolutionary trends [2, 4, 10, 12, 13] . Vaccines 2020, 8, 220 3 of 8 change alters the conformation of these immunogenic determinants; consequently, this region is expected to no longer act as a B-cell epitope in SARS-CoV-2b. The results of the antigenic index analysis showed severely reduced indexes of amino acids 615-617 in the SARS-CoV-2b strains compared to SARS-CoV-2a; it is predicted that the change of D614G affects the antigenicity of this region ( Figure 1F ).	./cache/cord-295830-1sbnewog.txt	./txt/cord-295830-1sbnewog.txt