id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-295508-yhdj5m0e	Yang, Li-Tao	Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients	2006-06-16		.txt	text/plain	4422	241	64	title: Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients In this study, we found that memory T-cell responses against the spike (S) protein were persistent for more than 1 year after SARS-CoV infection by detecting the production of IFN-γ using ELISA and ELISpot assays. In this study, we analyzed CD4 + and CD8 + T-cell responses in peripheral blood of recovered SARS patients to a pool of 169 overlapping SARS-CoV S peptides and characterized the phenotype of memory T-cell subpopulations. In this study, we performed phenotypic characterization of antiviral T-cell responses specific for SARS-CoV S peptides on the basis of their ability to secrete IFN-g and the expression of CD45RO, CCR7 and CD62L. Consistent with observations in HIV infection, we showed that SARS-CoV S-specific CD8 + T cells produced IFN-g but not IL-2 and predominantly displayed CD45RO À CCR7 À phenotype which might represent terminally differentiated effector memory T cells [25] .	./cache/cord-295508-yhdj5m0e.txt	./txt/cord-295508-yhdj5m0e.txt