id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-294498-fv545rfa	Spiegel, Martin	The antiviral effect of interferon-beta against SARS-Coronavirus is not mediated by MxA protein	2004-07-31		.txt	text/plain	1276	83	59	title: The antiviral effect of interferon-beta against SARS-Coronavirus is not mediated by MxA protein In this study, we demonstrated that multiplication of SARS-CoV in cell culture can be strongly inhibited by pretreatment with interferon-beta. In this study, we investigated the potential of different IFNs to inhibit replication of SARS-CoV in cell culture and determined whether the human MxA protein contributes to the antiviral effect of type I IFNs. African green monkey kidney (Vero) cells were grown in Dulbecco's modified Eagle's medium containing 10% fetal calf serum. We investigated the inhibitory effect of type I and II IFNs on SARS-CoV multiplication in cell culture. Therefore, we tested growth of SARS-CoV in Vero cell lines which stably express MxA (Frese et al., 1995) . Thus, the search for antiviral effects against SARS-CoV should focus on other IFN-induced proteins such as PKR or RNase L.	./cache/cord-294498-fv545rfa.txt	./txt/cord-294498-fv545rfa.txt