id author title date pages extension mime words sentences flesch summary cache txt cord-294295-sd5893ii Badua, Christian Luke D.C. Genomic and Proteomic Mutation Landscapes of SARS‐CoV‐2 2020-09-24 .txt text/plain 3432 193 57 The overall frequency and densities of mutations in the genes and proteins of SARS‐CoV‐2 were observed Nucleocapsid exhibited the highest mutation density among the structural proteins while the Spike D614G was the most common, occurring mostly in genomes outside China and USA. Altogether, approximately similar proportions of nucleotide change types were observed between genomes among the geographical areas collected from December-March 2020 versus December-May 2020 ( Figure 3B , 3C). All in all, the ORF7b gene/protein was observed to have no mutations in all geographical region and between the study timepoints, therefore this gene may be potentially conserved in SARS-CoV-2. In conclusion, this study highlights the importance of the characterization of both nucleotide and amino acid mutation landscape in SAR-CoV-2 to identify hotspots and coldspots that may be significant in the effectivity of diagnostic tools and treatment options for COVID-19, over the different areas worldwide as the pandemic continues. ./cache/cord-294295-sd5893ii.txt ./txt/cord-294295-sd5893ii.txt