id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-294199-o8w35pdy	Zhang, Qiangzhe	Cellular Nanosponges Inhibit SARS-CoV-2 Infectivity	2020-06-17		.txt	text/plain	2222	132	48	Inspired by the fact that the infectivity of SARS-CoV-2 relies on its binding with the protein receptors, either known or unknown, on the target cells, we create cellular nanosponges as a medical countermeasure to the coronavirus. SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) and CD147 expressed on the host cells, such as human alveolar epithelial type II cells, as receptors for cellular entry. To further verify that the inhibition was indeed due to epithelial cell or macrophage membrane coating, control nanosponges made from membranes of red blood cells (denoted "RBC-NS") were also tested in parallel for viral inhibition but were not effective in neutralizing SARS-CoV-2 infection of Vero E6 cells ( Figure 3C ). In principle, as long as the target of the virus remains the identified host cell, the nanosponges will be able to neutralize the infection, providing a broad-acting countermeasure resistant to mutations and protection against this and other emerging coronaviruses.	./cache/cord-294199-o8w35pdy.txt	./txt/cord-294199-o8w35pdy.txt