id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-294134-o9bx1gn7	Brecher, Stephen M.	Patients with Common Cold Coronaviruses Tested Negative for IgG Antibody to SARS-CoV-2	2020-07-23		.txt	text/plain	745	44	51	One early issue in the validation/ evaluation of antibody tests for evidence of SARS-CoV-2 infection is the possibility of cross-reacting antibodies from the plasma of patients who had been infected with one or more of the common cold coronaviruses (coronavirus 229E, HKU1, NL63, and OC43). It also ties in with issues outlined in the Infectious Diseases Society of America (IDSA) guidelines (4) and in a commentary in Lancet (5) on how to best utilize antibody test data, especially when there could be false-positive results, including cross-reacting antibodies to the four common cold coronaviruses. Although the sample size was minimal, these data are reassuring that at least for the Abbott Architect SARS-CoV-2 antibody test, plasma from patients with documented positive PCRs for these four common cold coronaviruses did not test positive for the SARS-CoV-2 IgG antibody. However, this multisite study, including data from 3 regional Veterans Affairs (VA) institutions (MA, CT, and VT) suggests that cross-reacting antibodies are not detected when testing for SARS-CoV-2 IgG antibody.	./cache/cord-294134-o9bx1gn7.txt	./txt/cord-294134-o9bx1gn7.txt