id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-293991-x5zdo8t2	Wheatley, A. K.	Evolution of immunity to SARS-CoV-2	2020-09-10		.txt	text/plain	4622	333	56	While SARS-CoV-2 specific B and T cell responses are readily induced by infection, the longitudinal dynamics of these key memory populations remains poorly resolved. We find that binding and neutralising antibody responses, together with individual serum clonotypes, decay over the first 4 months post-infection, as expected, with a similar decline in S-specific CD4+ and circulating T follicular helper (cTFH) frequencies. Serum inhibition of RBD-ACE2 binding and S1-specific IgG 106 responses in early infection were also well correlated with neutralisation titre in late 107 convalescence (Spearman rho=0.79, 0.81, respectively; Extended Data Fig 3) . S-specific cTFH and conventional CD4+ 152 and CD8+ memory T cells (Tmem), were quantified using activation induced marker 153 (AIM) assays 19,22 (Methods) following stimulation with overlapping S (split into S1 154 or S2) peptide pools (Fig. 3A, 3B ). SARS-CoV-2 infection induces sustained humoral immune 623 responses in convalescent patients following symptomatic COVID-19.	./cache/cord-293991-x5zdo8t2.txt	./txt/cord-293991-x5zdo8t2.txt