id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-293860-6kz0iws6	Qutayba Almerie, Muhammad	The Association between Obesity and Poor Outcome after COVID-19 Indicates a Potential Therapeutic Role for Montelukast	2020-05-27		.txt	text/plain	2801	139	41	HYPOTHESIS: Through a direct anti-viral effect, or by suppression of heightened cytokine release in response to SARS-CoV2, montelukast will reduce the severity of immune-mediated multiorgan damage resulting from COVID-19, particularly in patients with central obesity and metabolic syndrome. Through a direct anti-viral effect, or by suppression of heightened cytokine release in response to SARS-CoV2, montelukast will reduce the severity of immune-mediated multiorgan damage resulting from COVID-19, particularly in patients with central obesity and metabolic syndrome. With its prominent effect in reducing leukotriene-mediated cytokine release montelukast would have the potential to moderate the background inflammation associated with obesity and the body's inflammatory response to SARS-CoV2. The strong association between the pro-inflammatory state found in metabolic syndrome and obesity and a more aggressive clinical course in COVID-19 suggests a potential treatment role for drugs that inhibit cytokine release and macrophage activation.	./cache/cord-293860-6kz0iws6.txt	./txt/cord-293860-6kz0iws6.txt