id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-293765-xpc4yizb	Huang, Jia-Ling	Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome()	2005-02-24		.txt	text/plain	5149	250	53	To define the dynamics of the immune spectrum in SARS, serum levels of cytokines, chemokines, immunoglobulins, complement and specific antibodies against SARS-associated coronavirus (SARS-CoV) were assayed by enzyme-linked immunosorbent assay (ELISA), and phenotypes of peripheral lymphocytes were analyzed by flow cytometry in 95 SARS-infected patients. IL-10 levels in the serum of SARS patients were continuously elevated for the 5 months observed in this study (2.47-4 .57 times that of normal control levels; Fig. 1C , P < 0.001, correlation coefficient = 0.514, one-way ANOVA; minimum detectable dose < 3.9 pg/ml). In this study, we found that infection with SARS-CoV triggered vigorous immune disturbances characterized by the following: (1) typical anti-viral nonspecific and specific humoral responses; (2) perturbation of cytokine and chemokine levels; and (3) severe impairment of cellular immunity, including lymphopenia in acute phase and loss of CD8+ memory T cells in convalescent phase.	./cache/cord-293765-xpc4yizb.txt	./txt/cord-293765-xpc4yizb.txt