id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-293578-yu2i0u2h	Kusadasi, Nuray	A Pathophysiological Perspective on the SARS-CoV-2 Coagulopathy	2020-08-10		.txt	text/plain	3914	259	38	The potential role of plasma kallikrein in case of SARS-CoV-2 infection may be summarized as (1) the activation of FXII with the end-product thrombin (coagulation system) (2) the generation of bradykinin with subsequent vascular permeability and leakage (kallikrein-kinin system), (3) the activation of the renin-angiotensin system through conversion of renin from pre-renin leading to a pro-inflammatory state through increased angiotensin 1 receptor activation and (4) the activation of C5, in part through activation of C1 via FXII and in part through activation of C3 via plasmin (complement system). 54, 55 Since prekallikrein is seen as a potential regulator in the fibrin clot formation through FXII activation and is involved in the pathogenesis of thrombosis, there might be an important role for controlling the hypercoagulable state of the patients infected with SARS-CoV-2 as a therapeutic target. Taken together, all these mechanisms may contribute to the complex hypercoagulable state of the critically ill patients infected with SARS-CoV-2 having severe hypoxia and ongoing endothelial activation.	./cache/cord-293578-yu2i0u2h.txt	./txt/cord-293578-yu2i0u2h.txt