id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-293415-u9onutny	Amendola, A.	Human cardiac stromal cells exposed to SARS-CoV-2 evolve into hyper-inflammatory/pro-fibrotic phenotype and produce infective viral particles depending on the levels of ACE2 receptor expression	2020-11-10		.txt	text/plain	3522	214	50	title: Human cardiac stromal cells exposed to SARS-CoV-2 evolve into hyper-inflammatory/pro-fibrotic phenotype and produce infective viral particles depending on the levels of ACE2 receptor expression Our findings indicate that human cardiac stromal cells have a susceptibility to SARS-CoV-2 infection and produce variable viral yields depending on the extent of cellular ACE2 receptor expression. The susceptibility of the myocardial tissue to SARS-CoV-2 infection Tavazzi et al., 2020) has been inferred based on the expression of the Angiotensin-Converting Enzyme-2 (ACE2) receptor in various cardiac cell types (Zou et al., 2020) , and the evidence that the virus interacts with this receptor via the Spike (S) protein, as a main cellular docking/internalization site . Together, these results highlight an additional cardiac pathogenesis mechanism by SARS-CoV-2 independent of ACE2 expression, consisting of substantial upregulation of genes involved in response to viral infection, intercellular virus transmission and related to innate immunity signaling and fibrotic activation.	./cache/cord-293415-u9onutny.txt	./txt/cord-293415-u9onutny.txt