id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-292580-caxb9ob9	Chang, Z	RNAi therapeutics: Can siRNAs conquer SARS?	2005-11-10		.txt	text/plain	1311	95	60	The epidemic of the severe acute respiratory syndrome (SARS) [1] [2] [3] in 2003 heightened the necessity for us to develop strategies to cope with emerging infectious diseases. Recent work has also shown that selected siRNAs can effectively inhibit SARS-CoV replication in cultured cells. This new study provided, for the first time, the evidence that siRNAs have a significant effect on suppression of SARS-like symptoms in a macaque model. The authors' results indicated that the SARS-CoV-infected monkeys had attenuated SARS-like symptoms when the animals were treated with siRNA duplexes. Rhesus macaque is a good model for studying human SARS-CoV infections. Although this approach is obviously not a cure for SARS since the treated animals also developed SARS symptoms, it can be used as a complementary strategy to reduce the severity of the disease and to low the viral load in patients.	./cache/cord-292580-caxb9ob9.txt	./txt/cord-292580-caxb9ob9.txt