id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-291738-nak5357h	Padoan, Andrea	Clinical performances of an ELISA for SARS-CoV-2 antibody assay and correlation with neutralization activity	2020-08-18		.txt	text/plain	1111	66	49	Here we describe the clinical performances of an ELISA (Novalisa NovaTec Immunodiagnostica, Dietzenbach, Germany) for the detection of SARS-CoV-2 IgA, IgM and IgG and the comparison of results with the neutralization activity. A total of 171 leftover serum samples from 41 SARS-CoV-2 negative subjects (20 healthcare workers, 13 autoimmune patients, 8 pregnant women) and 130 COVID-19 patients (9 asymptomatic/mildly symptomatic recovered at home with supportive care and isolation, and 121 hospitalized, classified with moderate or severe disease following WHO interim guidance [5] ) were included in the study. As expected, when the time frame < 12 days was considered, the diagnostic sensitivity of the three assays was very limited and the best performances were found for IgA with a sensitivity equal to 65%, thus confirming our previously reported findings, as in most patients increased antibody levels should be detected only after 6-7 days post symptom onset (PSO) [7] [8] [9] . Evaluation of an ELISA for SARS-CoV-2 antibody testing: clinical performances and correlation with plaque reduction neutralization titer	./cache/cord-291738-nak5357h.txt	./txt/cord-291738-nak5357h.txt