id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-291459-m56dy8us	Hraiech, Sami	Lack of viral clearance by the combination of hydroxychloroquine and azithromycin or lopinavir and ritonavir in SARS-CoV-2-related acute respiratory distress syndrome	2020-05-24		.txt	text/plain	1152	64	52	In order to evaluate these results in intensive care unit (ICU) patients, we retrospectively assessed in moderate-to-severe ARDS the efficacy of hydroxychloroquine-azithromycin combination regarding viral disappearance at both day 6 of the treatment and day 6 of evolution of ARDS as compared with patients treated with lopinavir-ritonavir and a control group without any anti-viral treatment. Negative nasopharyngeal PCR for SARS-CoV-2 at day 6 following the initiation of treatment were observed in 5 (38%) patients from the lopinavir-ritonavir group as compared with 3 (18%) patients from the hydroxychloroquine-azithromycin group and 2 (20%) from the control group (p = 0.39). At day 6 following ARDS onset, PCR was negative in only 9 patients, 5 from the lopinavir-ritonavir group, 2 from the hydroxychloroquine-azithromycin group and 2 from the control group.	./cache/cord-291459-m56dy8us.txt	./txt/cord-291459-m56dy8us.txt