id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-291356-df5n5v09	Verma, Saguna	ACE2 receptor expression in testes: implications in coronavirus disease 2019 pathogenesis	2020-05-19		.txt	text/plain	1279	71	49	Expression of angiotensin-converting enzyme 2, receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is high in the testes, therefore SARS-CoV-2 infection and its association with male reproductive health should be investigated in male coronavirus disease 2019 patients. SARS-CoV-2 infection is robust in cells expressing angiotensinconverting enzyme 2 (ACE2) receptor, a type I integral membrane protein that controls cardiac and kidney functions by negatively regulating renin-angiotensin systems [2] . High ACE2 expression may augment virus infection in the lung, heart, and small intestine that might explain the pathophysiology of acute lung and myocardial injury, and gastrointestinal symptoms reported in COVID-19 patients [1] . Cytokines and chemokines induced by SARS-CoV-2 entry into the LC and SC may recruit peripheral immune cells including macrophages and virus-specific T cells that may further potentiate inflammation and orchitis in accordance with reported symptoms from 19% of patients in study by Pan et al.	./cache/cord-291356-df5n5v09.txt	./txt/cord-291356-df5n5v09.txt