id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-291194-cl3nu5cm	DURDAĞI, Serdar	Virtual drug repurposing study against SARS-CoV-2 TMPRSS2 target	2020-06-21		.txt	text/plain	2146	136	54	One of the important SARS-CoV-2 targets namely type 2 transmembrane serine protease (TMPRSS2) was screened with NPC's NIH small molecule library which includes approved drugs by FDA and compounds in clinical investigation. The small molecules from NCGC-NIH Chemical Genomics Center Pharmaceutical Collection (i.e. NPC library) were used in virtual screening studies at the active site of developed TMPRSS2 model target protein. Interestingly, benzquercin was also found as potent hit compounds in our previous virtual screening study using same protocol against another important cellentry target of SARS-CoV-2 Spike/ACE2 (Durdagi et al., 2020) . In this study, a virtual drug repurposing study was performed to identify new compounds against TMPRSS2 which is an important target for the entry of the SARS-CoV-2 to the host cell. Screening of Clinically Approved and Investigation Drugs as Potential Inhibitors of SARS-CoV-2 Main Protease and Spike Receptor-Binding Domain Bound with ACE2 COVID19 Target Proteins: A Virtual Drug Repurposing Study	./cache/cord-291194-cl3nu5cm.txt	./txt/cord-291194-cl3nu5cm.txt