id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-291149-j70b7kyi	Leuzinger, K.	Epidemiology and precision of SARS-CoV-2 detection following lockdown and relaxation measures	2020-09-23		.txt	text/plain	5480	369	55	Aim: To cross-validate manual and automated high-throughput (Roche-cobas6800-Target1/Target2) testing for SARS-CoV-2-RNA, to describe detection rates following lockdown and relaxation, and to evaluate SARS-CoV-2-loads in different specimens. As comprehensive real-life data are scarce, we analyze the epidemiology of SARS-CoV-2detection following lockdown and relaxation measures and investigate the quantitative relationship of the different assays and explore SARS-CoV-2-loads in follow-up NOPS and in time-matched lower respiratory fluids, and in plasma samples. Basel-S-gene RT-QNAT was used for SARS-CoV-2 genome quantification in 936 follow-up NOPS from 261 patients with a positive Roche-Cobas-Target1/Target2 screening result, in 95 NOPS and time-matched lower respiratory fluids (tracheal aspirates, bronchial-alveolar lavage, or sputum) or in 259 NOPS and time-matched plasma samples from COVID-19 patients. To follow the SARS-CoV-2-detection rates after introducing more stringent lockdown measures in Switzerland in calendar week 12 (https://www.bag.admin.ch/bag/en/home/dasbag/aktuell/medienmitteilungen.msg-id-78454.html), we identified all NOPS from 12'363 symptomatic adults and children tested for SARS-CoV-2 from calendar week 14 to 24 (Follow-up cohort-1; Table 1 ) including 270 (2%) confirmed infections ( Figure 3A) .	./cache/cord-291149-j70b7kyi.txt	./txt/cord-291149-j70b7kyi.txt