id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-291014-cfnoxhtd	Zheng, Jian	Immune responses in influenza A virus and human coronavirus infections: an ongoing battle between the virus and host	2018-02-28		.txt	text/plain	4394	261	32	In one example, our studies of mice infected with SARS-CoV showed that the severity of SARS correlated with the ability to develop a virus-specific immune response, while inhibitory alveolar macrophages and inefficient activation of dendritic cells (DCs) delayed this process and aggravated disease [1] . The CoV endonuclease, nsp15, efficiently prevented activation of host cell dsRNA sensors including melanoma differentiation-associated protein 5 (Mda5), 2 0 -5 0 oligoadenylate synthetase (OAS) and PKR [93, 94 ] , while coronavirus-encoded proteases countered innate immunity, including the IFN response, through diverse pathways [95] . Glycosylation of the HA protein not only mediated virus entry into host cells [115] [116] [117] , but also modulated IAV replication and transmission [118] , and the immune response against the virus [119] [120] [121] , thus representing a potential target for vaccine and drug development [122, 123 ] .	./cache/cord-291014-cfnoxhtd.txt	./txt/cord-291014-cfnoxhtd.txt