id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-290443-naulq6q7	Battistoni, Allegra	Might renin–angiotensin system blockers play a role in the COVID-19 pandemic?	2020-04-14		.txt	text/plain	2219	128	50	15, 16 Therefore, the higher ACE2 expression due to chronically medicating SARS-CoV-2-infected patients with ARB may protect them against acute lung injury by blocking the deleterious effect of angiotensin II, as well as by decreasing the production of angiotensin II by up-regulating ACE2, which in turn increases the production of angiotensin (1-7). 33-36 Moreover, even though ACEIs and ARBs might increase ACE2 levels in the lungs, this might not be relevant to SARS-CoV-2 infection. [38] [39] [40] [41] [42] [43] For the second aim, not only case series, but also autoptic exams should investigate the expression and activation of RAS components in different organs during COVID-19 infection in patients treated or not with an ACEI/ARB, also investigating ACE2 polymorphisms which could impact the affinity for the spike protein of SARS-CoV-2. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury	./cache/cord-290443-naulq6q7.txt	./txt/cord-290443-naulq6q7.txt