id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-290056-x74cq2k5	Delgado-Roche, Livan	Oxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) infection	2020-04-30		.txt	text/plain	1910	103	43	title: Oxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) infection Some authors suggest that the onset of severe lung injury in SARS-CoV infected patients depends on activation of the oxidative stress machinery that is coupled with innate immunity and activates transcription factors, such as NF-κB, resulting in an exacerbated proinflammatory host response (14) . Activation of the PI3K/Akt signaling pathway may lead to a delay in Oxidative stress -NF-kB -toll-like receptor (mainly TL4) signaling pathways, triggered by viral pathogens like SARS-CoV, may further amplify the host inflammatory response, ultimately leading to acute lung injury. In conclusion, literature evidence suggests that oxidative stress and chronic low-grade inflammation in the lungs are associated with aging and may contribute to age-related immune dysfunction and mortality risk in aged patients affected by respiratory virus infections, such as SARS-CoV-2.	./cache/cord-290056-x74cq2k5.txt	./txt/cord-290056-x74cq2k5.txt