id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-288998-0by0bkgs	Colarusso, Chiara	A lesson from a saboteur: high molecular weight kininogen (HMWK) impact in COVID‐19	2020-06-04		.txt	text/plain	3857	211	45	In the attempt to understand how the virus spreads and how to pharmacologically abolish it, it was highlighted that SARS‐CoV‐2 infects human cells by means of angiotensin converting enzyme 2 (ACE2), transmembrane protease serine 2 (TMPRSS2) and SARS‐CoV‐2 main protease (M(pro)). Our attention has been focused on the role of ACE2 in that its blockade by the virus increases Bradykinin and its metabolites, well known to facilitate inflammation in the lung (responsible for cough and fever), facilitate both the coagulation and complement system, three mechanisms that are typical of angioedema, cardiovascular dysfunction and sepsis, pathologies which symptoms occur in COVID‐19 patients. Once SARS-CoV-2 binds to ACE2 , the enzyme is blocked, therefore, leading to what we are actually assisting in terms of high blood pressure in COVID-19 patients and pulmonary edema up to angioedema, which underlies the fact that physiologically ACE2 cleaves several bioactive peptides, among which [des-Arg 9 ]bradykinin ([des-Arg 9 ]BK) (Vickers et al.	./cache/cord-288998-0by0bkgs.txt	./txt/cord-288998-0by0bkgs.txt