id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-288670-1vlowf2n	Yang, Naidi	Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19	2020-03-15		.txt	text/plain	4511	207	45	As a result, the endocytic pathway including endosome and lysosome has become important targets for development of therapeutic strategies in combating diseases caused by CoVs. In this mini-review, we will focus on the importance of the endocytic pathway as well as the autophagy process in viral infection of several pathogenic CoVs inclusive of SARS-CoV, MERS-CoV and the new CoV named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and discuss the development of therapeutic agents by targeting these processes. Further studies also demonstrated that either ATG5 or ATG7, two of the key autophagy proteins in control of autophagosome biogenesis, is not required for viral replication in cells infected by MHV [28, 29] or by SARS-CoVs [30] . Taken together, establishing the role of endocytic pathway in viral entry is a major breakthrough in the mechanistic understanding of the CoVs infection, which offers great opportunity in development of novel therapeutic strategies for treatment of diseases such as SARS and COVID-19.	./cache/cord-288670-1vlowf2n.txt	./txt/cord-288670-1vlowf2n.txt