id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-288632-2aliqy8p	Phillips, Nicole	The Perfect Storm: COVID-19 Health Disparities in US Blacks	2020-09-23		.txt	text/plain	4575	210	36	Specifically, Fig. 1 illustrates a conceptual model through which psychological influences (stress, anxiety, depression), pre-existing/comorbid disease (e.g., HTN, T2DM), and COVID-19 interconnect on the basis of known and unknown genetic variations that translate into human health outcomes and molecular modes of viral pathogenesis. Importantly, it is the interplay between key environmental exposures (stress; social determinants of health, SDH) and genetic predisposition for aspects of viral pathogenesis and/or comorbid disease (e.g., type 2 diabetes mellitus, T2DM; hypertension, HTN) that ultimately converges on COVID-19 manifestation and affects mortality . While there is conflicting data regarding the effects of variants in all three of the candidate genes discussed here, the remarkable relevance of associated phenotypes to COVID-19 pathophysiology together implies that genetic polymorphisms which regulate immune and stress responses may interact to affect underlying disease risk and, simultaneously, SARS-CoV-2 pathogenicity.	./cache/cord-288632-2aliqy8p.txt	./txt/cord-288632-2aliqy8p.txt