id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-288357-3mqoexcr	Liu, Pei	Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds	2020-08-01		.txt	text/plain	1882	148	61	title: Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds We identified several N-substituted isatin compounds as potent SARS-CoV-2 3C-like protease inhibitors. [4, [9] [10] [11] [12] To date, several potential SARS-CoV-2 3CL pro inhibitors have been reported from compound library screening, [8] rational design [8, 13] , [14] and testing of ingredients from traditional Chinese medicine. Previously, we reported a series of N-substituted 5-carboxamide-isatin compounds as inhibitors of SARS CoV 3CL pro . [12] Apparently, the isatin scaffold with derivatization may also provide a good starting point for SARS CoV-2 3CL pro inhibitor development, because the two proteases share high sequence identity and the same active site. In conclusion, we have tested the inhibition activity of 29 N-substituted isatin derivatives against SARS-CoV-2 3CL pro . Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors substituted isatin compounds are potent SARS-CoV-2 3C-like protease inhibitors.	./cache/cord-288357-3mqoexcr.txt	./txt/cord-288357-3mqoexcr.txt