id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-288066-sh6n2c3n	Mohamed, Mohamed S.	Sex differences in COVID-19: the role of androgens in disease severity and progression	2020-11-11		.txt	text/plain	2489	155	41	Variants in the androgen receptor gene correlate with androgen sensitivity and are implicated in diseases like androgenetic alopecia and prostate cancer, conditions that have been associated with worse COVID-19 outcomes and hospitalization. The proposed mechanism behind this effect is based on the idea that androgen receptor and, subsequently, TMPPRSS2 expression affects the SARS-COV2 virus ability to enter host cells and its spike proteins affinity to bind ACE2 receptors (Fig. 1 ). SARS-CoV2 spike proteins are then primed by TMPRSS2, allowing the interaction with ACE2 receptors to enter host cells Fig. 2 Theoretical mechanisms suggesting CAG repeats length and associated androgen sensitivity as a predictor for COVID-19 disease severity lack of control groups or testosterone levels prior to infection, the results warrant consideration. Increased androgen receptor expression might lead to a higher risk of acquiring a severe COVID-19 disease by promoting TMPRSS2 transcription (Fig. 2) . Androgen Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men	./cache/cord-288066-sh6n2c3n.txt	./txt/cord-288066-sh6n2c3n.txt