id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-288017-f9b3t0ts	Kabeerdoss, Jayakanthan	Understanding immunopathological fallout of human coronavirus infections including COVID‐19: Will they cross the path of rheumatologists?	2020-08-10		.txt	text/plain	4281	280	46	High risks for fatal disease in COVID‐19 include older age, metabolic syndrome, male gender, and individuals who develop delayed type I IFN response. 54 In a macaque model of SARS-CoV infection too, aged macaques had more severe lung pathology, lower expression of type I IFN and higher expression of pro-inflammatory cytokines as compared to younger macaques. 80 to patients with COVID-19 that it is a mild immunomodulatory F I G U R E 2 Hydroxychloroquine (HCQ) inhibits SARS-CoV-2 entry and inhibits virus-induced type I interferon (IFN) signaling and proinflammatory cytokines production. While male gender, older age and people with metabolic syndrome seem to be at a higher risk of contracting more severe SARS-CoV-2 infection, younger females of African and Asian ancestry have higher risk for developing SLE; male gender among lupus patients, however, is an independent risk factor for severe disease. Evasion by stealth: inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice	./cache/cord-288017-f9b3t0ts.txt	./txt/cord-288017-f9b3t0ts.txt