id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-287682-97fquq16	Daubin, Cédric	Is a COPD patient protected against SARS-CoV-2 virus?	2020-10-03		.txt	text/plain	745	55	50	In addition, cigarette smoke and COPD were reported to up-regulate Angiotensin-converting enzyme 2 (ACE-2) expression, which plays a key role in the pathogenesis of SARS-CoV-2 in lower airways [2] . Considering a significant inverse relationship between ACE-2 gene expression and the severity of COPD [2] , one hypothesis could be that COPD protects against SARS-CoV-2 through a TMPRSS2 inhibitor activity or by an a downregulation of the inflammatory pathway limiting severe forms of infection. Interestingly, as reported by Halpin et al., inhaled corticosteroids, used by COPD patients can reduce the risk of viral infection. Therefore, inhaled corticosteroids in combination with bronchodilators could limit expression or activity of transmenbrane serine protease TMPRSS2 which facilitates SARS-CoV-2 entry in cells. Surprisingly current smokers (i.e., a large part of COPD patients) could be protected against SARS-CoV-2 infection [4] . Sin DD (2020) ACE-2 Expression in the Small Airway Epithelia of Smokers and COPD Patients: Implications for COVID-19	./cache/cord-287682-97fquq16.txt	./txt/cord-287682-97fquq16.txt