id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-286895-i3g4ad4z	Panciani, Pier Paolo	SARS-CoV-2: “Three-steps” infection model and CSF diagnostic implication	2020-05-05		.txt	text/plain	772	61	52	Dear Editor, An increasing number of Coronavirus Disease 2019 (COVID-19) patients shows neurological symptoms, but currently few studies have systematically analyzed the impact of SARS-CoV-2 on the Central Nervous System (CNS). (Bertran Recasens et al., 2020) In our Department we observed 3 different clinical pictures in SARS-CoV-2 infection with neurological impairment: cerebral thrombosis (CTh) with hemorrhagic infarction, demyelinating lesions and encephalopathy. SARS-CoV-2 may lead to Neuro-COVID through three phases ( Fig.1) : neuroinvasion, CNS clearance and immune response. Negative results could also be explained by the lack of apoptosis and/or necrosis as observed in pre-clinical models (Netland et al., 2008) , the lowsensitivity of the method and the CSF clearance of SARS-CoV-2 that lead to a low viral below the sensitivity of currently available instrumentation. In the last phase, the respiratory system is severely affected leading to potential hypoxia with subsequent brain damage.	./cache/cord-286895-i3g4ad4z.txt	./txt/cord-286895-i3g4ad4z.txt