id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-285944-8lapwnuw	Suwanwongse, Kulachanya	Hyperpyrexia in COVID‐19 patients	2020-06-10		.txt	text/plain	2171	124	39	We propose three possible underlying mechanisms based on our current knowledge: 1) direct brain injury from SARS-CoV-2, 2) persistent immune dysfunction and dysregulation of cytokines, and 3) vascular thrombosis. According to our case series, the lack of normal daily temperature variation in patient 4 and 5, and the presence of hypothermia in patient 1 and 5 support the hypothesis that direct brain injury from SARS-CoV-2 leads to hyperpyrexia. SARS-CoV-2 may cause injury to the brain-stem respiratory center explaining why COVID-19 patients often report lesser perception of dyspnea than the actual degree of hypoxia and the extent of lung pathology [15] . Our case series also highlights the need to determine underlying mechanisms of hyperpyrexia in COVID-19 patients as each cause requires different management. The underlying mechanisms of hyperpyrexia in COVID-19 are unknown but may be a result of SARS-CoV-2 related brain injury, exuberant immune response, and thrombus formation.	./cache/cord-285944-8lapwnuw.txt	./txt/cord-285944-8lapwnuw.txt