id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-284873-m1ehdydr	Cadegiani, Flavio A.	Spironolactone: An Anti-androgenic and Anti-hypertensive Drug That May Provide Protection Against the Novel Coronavirus (SARS-CoV-2) Induced Acute Respiratory Distress Syndrome (ARDS) in COVID-19	2020-07-28		.txt	text/plain	2536	158	38	title: Spironolactone: An Anti-androgenic and Anti-hypertensive Drug That May Provide Protection Against the Novel Coronavirus (SARS-CoV-2) Induced Acute Respiratory Distress Syndrome (ARDS) in COVID-19 At the onset of the COVID-19 pandemic, mortality following infection of severe acute respiratory coronavirus (SARS-CoV-2) was thought to be solely associated with aging and pre-existing conditions; however, as the pandemic ensued, several large scale epidemiological observations eluded to additional atypical risk factors, particularly hypertension, obesity, and male gender (1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) . The Renin-Angiotensin-Aldosterone System (RAAS) has been shown to be central in COVID-19, since three of the key modulators of SARS-CoV-2 infectivity-angiotensin 1-7, ACE2, and AT1-belong to the RAAS, in addition to the TMPRSS2 expression (12) (13) (14) (15) (16) (17) (18) (19) . Abnormal ACE2 expression, angiotensin II and angiotensin 1-7 imbalance, and TMPRSS2 androgen-mediated overactivity seem to be key regulators of SARS-CoV-2 infectivity, in accordance with epidemiological observations of hypertension, obesity, and male sex as being major risk factors.	./cache/cord-284873-m1ehdydr.txt	./txt/cord-284873-m1ehdydr.txt