id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-284559-g9szoh3g	Bartoloni, Elena	Hypertension and SARS-Cov-2 infection: is inflammation the missing link?	2020-09-23		.txt	text/plain	616	50	33	The dramatic emergence of the pandemic coronavirus disease COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raised significant medical and public health concerns for the high disease mortality rate ranging from 1% to more than 5%. 2 In fact, pre-existing cardiovascular comorbidities, including hypertension (HTN), diabetes mellitus, cerebrovascular and coronary heart disease, enhance susceptibility to SARS-CoV-2 infection and are associated with increased risk of severe disease, myocardial injury and short-term mortality rate. 4 However, due to the high prevalence of hypertension in the general population, concerns raised as to whether hypertension represents merely a concomitant risk factor or a pivotal pathogenic trigger of cardiac injury in patients with SARS-CoV2 infection. In this setting, it may be hypothesized that COVID-19associated PAMPs may act as exogenous triggers of TLR4 signalling pathway leading to inflammasome activation and inflammatory cytokine release, including interleukin-1 (Figure) .	./cache/cord-284559-g9szoh3g.txt	./txt/cord-284559-g9szoh3g.txt