id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-284478-c1uj3jra	Schub, David	High levels of SARS-CoV-2–specific T cells with restricted functionality in severe courses of COVID-19	2020-10-15		.txt	text/plain	7277	364	48	RESULTS: Despite severe lymphopenia affecting all major lymphocyte subpopulations, patients with severe disease mounted significantly higher levels of SARS-CoV-2–specific T cells as compared with convalescent individuals. So far, mainly nonspecific general changes in the number and functionality of blood cells have been described, whereas specific T cell immunity directed against SARS-CoV-2 has as yet not been studied as extensively (7) (8) (9) (10) (11) , especially in patients with different disease severity. As shown in Figure 3A , the percentage of multifunctional, SARS-CoV-2-specific CD4 + T cells with the ability to simultaneously produce all 3 cytokines was significantly lower in patients with severe courses as compared with convalescent individuals. Nevertheless, the SEB-reactive and SARS-CoV-2-specific cytokine profiles exhibited similar differences between patients with severe disease and convalescent individuals ( Figure 3A ). We also analyzed expression of cytotoxic T lymphocyte antigen 4 (CTLA-4) on SARS-CoV-2-specific and SEB-reactive T cells as phenotypical correlates of altered functionality commonly observed during active infections.	./cache/cord-284478-c1uj3jra.txt	./txt/cord-284478-c1uj3jra.txt