id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-283850-kt8n6pg2	Steardo, Luca	Psychiatric face of COVID-19	2020-07-30		.txt	text/plain	7886	374	32	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), similarly to other coronaviruses demonstrate neurotropism; the viral infection of the brain stem may complicate the course of the disease through damaging central cardio-respiratory control. Post-mortem analysis of nervous tissue from tissue of a 54 years-old man who died from severe respiratory failure associated with COVID-19 identified SARS-COV-2 viral particles in the olfactory nerve, in the gyrus rectus and in the brainstem with signs of profound damage to all elements of the tissue including glial cells, neurones, their axons and myelin 37 . Infection with SARS-CoV-2 (even in moderate clinical cases) thus promotes cognitive disorders with emergence of delirium, acute psychosis, exacerbation of mild cognitive impairment or with accelerating of dementia associated with various neurodegenerative conditions, including Alzheimer's disease (AD) 85, 86 . Patients with COVID-19 could present with a wide range of neuropsychiatric symptoms, which result from systemic inflammation, CNS effects of cytokines, infection of neural cells by SARS-COV-2, neuroinflammation, glial dysfunction or aberrant epigenetic modifications of stress-related genes.	./cache/cord-283850-kt8n6pg2.txt	./txt/cord-283850-kt8n6pg2.txt