id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-283430-k1ex9fes	Smithgall, Marie C.	Third Trimester Placentas of SARS‐CoV‐2‐Positive Women: Histomorphology, including Viral Immunohistochemistry and in Situ Hybridization	2020-07-21		.txt	text/plain	1277	100	39	CONCLUSIONS: In this study, third trimester placentas from SARS‐CoV‐2‐positive women were more likely to show evidence of maternal/fetal vascular malperfusion; however, no evidence of direct viral involvement or vertical transmission was noted by ISH and IHC. Studies to date regarding SARS-CoV-2 and placental pathology have been limited by the number of SARS-CoV-2 positive cases, 4, 5 and only one with a sample size of 5 cases has utilized in-situ hybridization (ISH) and immunohistochemistry (IHC) analyses. 6 In our study, we compared placental histopathology from 51 SARS-CoV-2-positive and 25 SARS-CoV-2negative women in their third-trimesters presenting to L&D, and tested placentas from SARS-CoV-2-positive mothers using ISH and/or IHC. Placentas from SARS-CoV-2-positive women showed non-specific evidence of maternal/fetal vascular malperfusion, including subchorionic thrombi (Fig.1A) , intervillous thrombi (Fig.1B) , infarction (Fig.1C) , chorangiosis, segmental avascular-villi (Fig.1D) , fetal thrombotic vasculopathy (Fig.1E) , and villous agglutination (Fig.1F ).	./cache/cord-283430-k1ex9fes.txt	./txt/cord-283430-k1ex9fes.txt