id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-283193-8qj41kpp	Chak-Yiu Lee, Andrew	Oral SARS-CoV-2 inoculation establishes subclinical respiratory infection with virus shedding in golden Syrian hamsters	2020-09-22		.txt	text/plain	2326	139	51	title: Oral SARS-CoV-2 inoculation establishes subclinical respiratory infection with virus shedding in golden Syrian hamsters Utilizing Syrian hamster model, we demonstrate that the severity of pneumonia induced by intranasal inhalation of SARS-CoV-2 increases with virus inoculum. By 4 dpi, the hamsters infected with 10 2 or 10 3 PFU of SARS-90 CoV-2 also developed lung parenchymal damage which were milder than those observed in the 91 hamsters infected with 10 4 or 10 5 PFU of virus ( Figure 1D including both arteries and veins. The 133 intranasally infected hamsters had significantly higher viral load in oesophagus and stomach, but 134 no detectable virus in small intestinal tissues (n=3, Figure 2C ). In order to quantitatively compare the severity of lung damage after oral and intranasal 196 inoculation, we performed semi-quantitative histopathological evaluation of the bronchioles, 197 alveoli and blood vessels using a method modified from our previous influenza infection mouse 198 model and a reported hamster infection model (Table S1 ).	./cache/cord-283193-8qj41kpp.txt	./txt/cord-283193-8qj41kpp.txt