id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-282899-kp114q7n	Biswas, Saurav	Blood clots in COVID-19 patients: Simplifying the curious mystery	2020-11-06		.txt	text/plain	2501	138	38	Considering the above facts and recent unusual reports, a hypothesis develops for the blood clots formation in the COVID-19 patients (Figure 1) , states that "Due to an internal injury in the endothelium of blood vessels, either directly by SARS-CoV-2 infection (coexpression and binding of the spike protein with the ACE2) or my virus-mediated inflammatory immune response, may result in vasoconstriction and the activation of coagulation and blood clotting pathways, resulting in the formation of blood clots". During COVID-19 infection, SARS-CoV-2 enters into the systemic circulation and binds with the ACE2 expressing endothelial cells (endothelium) lining the blood vessels. SO, in COVID-19 patients, the SARS-CoV-2 mediated endothelial inflammation, thrombin generation, platelet, and leukocyte recruitment, complement activation, and the initiation of innate and adaptive immune responses, forming clots, culminate in immunothrombosis, ultimately resulting in thrombotic complications, stroke, and finally death.	./cache/cord-282899-kp114q7n.txt	./txt/cord-282899-kp114q7n.txt