id author title date pages extension mime words sentences flesch summary cache txt cord-282732-qym6wji7 McLaughlin, Katie-May COVID-19-Related Coagulopathy—Is Transferrin a Missing Link? 2020-07-30 .txt text/plain 2895 164 46 To identify gene products that may contribute to COVID-19-related coagulopathy, we analyzed the expression of genes associated with the Gene Ontology (GO) term "blood coagulation" in the Genotype-Tissue Expression (GTEx) database and identified four procoagulants, whose expression is higher in males and increases with age (ADAMTS13, F11, HGFAC, KLKB1), and two anticoagulants, whose expression is higher in females and decreases with age (C1QTNF1, SERPINA5). Thus, gene products that (1) are involved in coagulation, (2) change with age, (3) differ in their levels between females and males, and (4) are regulated in response to SARS-CoV-2 infection represent candidate factors that may contribute to COVID-19-related coagulopathy and disease severity. To identify such candidate factors that may be involved in COVID-19-related coagulopathy, we here performed a combined analysis of a proteomics dataset derived from SARS-CoV-2-infected cells [10] , of a dataset of host cell proteins found to bind to SARS-CoV-2 proteins [11] , and of human gene expression data from the Genotype-Tissue Expression (GTEx) database [12] . ./cache/cord-282732-qym6wji7.txt ./txt/cord-282732-qym6wji7.txt