id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-282539-skzosh6u	Casadevall, Arturo	Implications of Coronavirus Disease 2019 (COVID-19) Antibody Dynamics for Immunity and Convalescent Plasma Therapy	2020-08-17		.txt	text/plain	1588	75	45	The article by Wang et al in this issue of Clinical Infectious Diseases reports that neutralizing antibody titers to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus peak 4-5 weeks after the onset of symptoms and decline by 3 months [1] . The decline in neutralizing antibody titers measured by Wang et al [1] in 93.5% of the patients studied is concerning for it raises the possibility that like other coronaviruses, COVID-19 may not result in the establishment of long lasting immunity. Whereas implications of the kinetics of the antibody response to SARS-CoV-2 for long-lasting and vaccine-mediated immunity are uncertain, the results of Wang et al [1] are important for the development and use of antibody therapies. The finding that SARS-CoV-2 neutralizing titers declined relatively quickly in the Wang et al study [1] means that efforts to collect convalescent plasma with high titers of neutralizing antibody for therapy and hyper-immune globulin preparation need to be highly organized such that potential donors are contacted early in the weeks following COVID-19.	./cache/cord-282539-skzosh6u.txt	./txt/cord-282539-skzosh6u.txt