id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-282318-890mltl8	Richard, Mathilde	Factors determining human-to-human transmissibility of zoonotic pathogens via contact	2017-02-28		.txt	text/plain	3647	173	44	We used the following examples to illustrate these four modes of contact transmission: Treponema pallidum pertenue (TPE) for skin contact transmission, human immunodeficiency virus type 1 (HIV-1) for sexual contact transmission, coronaviruses (CoV) for respiratory contact transmission and Ebola virus for contact transmission via multiple routes. Other pathogen factors that have contributed to the 'success' of HIV-1 M strain as a human pathogen, despite its relatively low infectivity (risk estimate of 1 in 1000 exposures for heterosexual transmission; [9] ), include its extraordinary propensity to evolve its genome through recombination and low-fidelity replication, allowing immune and therapeutic escape [20] , the nature of its long, 'latent', often sub-clinical infection, during which patients can transmit the virus [21] , and high viral load. Amongst the pathogen factors that promote H2H transmission of Ebola virus is the high virus load in secreted bodily fluids combined with a very low infectious dose, as low as 10 plaque forming units as measured in experimental infection studies in nonhuman primates [56] .	./cache/cord-282318-890mltl8.txt	./txt/cord-282318-890mltl8.txt