id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-282133-5dzzm9s8	Watzky, Manon	Assessing the consequences of environmental exposures on the expression of the human receptor and proteases involved in SARS-CoV-2 cell-entry	2020-10-15		.txt	text/plain	5706	337	50	In here, exploiting a large panel of publicly available genome-wide data, we investigated whether the human receptor ACE2 and human proteases TMPRSS2, FURIN and CATHEPSINs (B, L and V), which are involved in SARS-CoV-2 cell entry, are transcriptionally regulated by environmental cues. We queried the comparative toxicogenomics database (CTD) to identify studies reporting changes in expression levels of human genes encoding receptor and proteases J o u r n a l P r e -p r o o f important for SARS-CoV-2 cell entry upon chemical exposure (Davis et al., 2019) . Using these criteria, we identified several chemical exposures regulating the expression of receptor ACE2 and human proteases TMPRSS2, FURIN and Cathepsins genes in human cells and tissues (Figure 2; Supplementary Table S2 ). Our analysis suggests that expression of human receptor and proteases of SARS-CoV-2 spike S glycoprotein are not directly regulated by cigarette smoke at the transcriptional level in lung cells, nor that PIR and ACE2 are coregulated upon cigarette smoke exposure.	./cache/cord-282133-5dzzm9s8.txt	./txt/cord-282133-5dzzm9s8.txt