id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-282108-hhnnloxp	Heister, Paula M.	Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID‐19	2020-09-15		.txt	text/plain	4037	253	49	The putative mechanism of action of tetrandrine that underlies its potential use as a coronavirus disease 2019 (COVID-19) treatment is its ability to block the two-pore channel 2 (TPC2) in host cells and thus inhibit virus replication at low micromolar concentrations. While this paper was in preparation, a large-scale study exploring SARS-CoV-2 human protein-protein interactions to identify potential therapeutic candidates identified verapamil as a contender, but initial in vitro screening did not show a promising effect at the concentrations used. If indicated by the above, clinical trials to investigate tetrandrine's potential, using an established oral dose, as an acute therapeutic or prophylactic agent against SARS-CoV-2 infection, provided safety can be confirmed for the particular length of use. 7. If indicated by the above, clinical trials to investigate the potential role of established calcium channel blockers as therapeutic agents in SARS-CoV-2 infection.	./cache/cord-282108-hhnnloxp.txt	./txt/cord-282108-hhnnloxp.txt