id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-282045-pf08iakf	Chen, Haoyan	Single cell transcriptome revealed SARS-CoV-2 entry genes enriched in colon tissues and associated with coronavirus infection and cytokine production	2020-07-08		.txt	text/plain	1676	105	60	title: Single cell transcriptome revealed SARS-CoV-2 entry genes enriched in colon tissues and associated with coronavirus infection and cytokine production The percentage of these five SARS-CoV-2 entry genes was similar as ACE2, which is gradually increased in epithelial cells from normal control, CRA to CRC samples (Supplementary Fig. S3d ). Strikingly, pathways associated with virus infection, inflammation and cytokine signaling were upregulated in six potential SARS-CoV-2 entry genes enriched cells (Fig. 1a) . Given that IL-6 and TNF pathways were upregulated in six potential SARS-CoV-2 entry genes enriched cells (Fig. 1a) , we compared the IL-6 and TNF-alpha levels in peripheral blood from mild (n = 102) and severe (n = 50) COVID-19 pneumonia patients Table S3 ). Here, we first proved that the six SARS-CoV-2 entry genes, including ACE2 and TMPRSS2, are expressed in the colon epithelial cells of Chinese adults. In a word, the expression of additional five SARS-CoV-2 entry genes, virus infection, and inflammatory pathways are significantly enriched in colon epithelia cells with ACE2-positive expression.	./cache/cord-282045-pf08iakf.txt	./txt/cord-282045-pf08iakf.txt